Last month we discussed new guidelines on antibiotic stewardship (see our July 2016 What's New in the Patient Safety World column “”) and in our several other prior columns on antibiotic stewardship listed below we’ve noted the overprescription of antibiotics for inappropriate indications, both in hospitals and ambulatory settings.
One such category where inappropriate antibiotic prescribing is rampant is the upper respiratory tract infection (RTI) that is usually self-limited and many of which are caused by viruses so are not amenable to antibiotic treatment. Many primary care practitioners remain concerned that failure to use antibiotics in such cases may lead to adverse consequences in their patients. They often have the impression that the primary reason for avoiding antibiotic prescribing is to prevent development of antibiotic-resistant organisms and that such concern applies to populations rather than to their individual patients. In fact, that’s not true as we discussed in our November 2015 What's New in the Patient Safety World column “Medications Most Likely to Harm the Elderly Are…” that the medications most likely to harm the elderly are antibiotics.
But it would be reassuring to see a study showing that avoidance of antibiotics in such cases is, in fact, safe. So a recent study done in 601 general practices in the UK provides such welcome reassurance. Researchers used data from the UK Clinical Practice Research Datalink (Gulliford 2016). They found that general practices that adopt a policy to reduce antibiotic prescribing for RTIs might expect a slight increase in the incidence of treatable pneumonia and peritonsillar abscess. However, there was no increase likely in mastoiditis, empyema, bacterial meningitis, intracranial abscess, or Lemierre’s syndrome.
They estimate that if a general practice with an average list size of 7000 patients reduces the proportion of RTI consultations with antibiotics prescribed by 10%, then it might observe 1.1 more cases of pneumonia each year and 0.9 more cases of peritonsillar abscess each decade. They conclude that even a substantial reduction in antibiotic prescribing was predicted to be associated with only a small increase in numbers of cases observed overall, but caution might be required in subgroups at higher risk of pneumonia.
An accompanying editorial (Del Mar 2016) also finds some reassurance in these findings. Some rapid response letters (Rapid Response 2016) note the importance of adequate early followup and cooperation of parents when treating pediatric patients. But another of the rapid response letters reveals a critical root cause of overprescribing antibiotics – the already harried general practitioner fears his workday will become overburdened by patients returning for an additional evaluation.
In our July 2016 What's New in the Patient Safety World column “”) we noted that CMS has announced that hospitals will be required to have antibiotic stewardship programs and demonstrate that they have reduced inappropriate antibiotic usage (CMS 2016). Now The Joint Commission has also revised its standard regarding antibiotic stewardship, effective January 1, 2017 (TJC, 2016).
Elements of the new TJC standard for include:
As a reminder, the seven CDC-defined core elements (CDC 2016) of a comprehensive antibiotic stewardship program are:
The TJC prebulication document also provides links to some useful tools, such as materials for educating patients and their families
See our columns listed below for ways to deal with the problem of inappropriate antibiotic prescribing and antibiotic stewardship programs both in the hospital and the ambulatory setting.
Some of our prior columns on antibiotic stewardship:
Gulliford MC, Moore MV, Little P, et al. Safety of reduced antibiotic prescribing for self limiting respiratory tract infections in primary care: cohort study using electronic health records. BMJ 2016; 354: i3410 (Published 04 July 2016)
Del Mar C. Antibiotics for acute respiratory tract infections in primary care. BMJ 2016; 354: i3482 (Published 05 July 2016)
Rapid Responses. Antibiotics for acute respiratory tract infections in primary care. BMJ 2016; 354: i3482 (Published 05 July 2016)
CMS (Centers for Medicare & Medicaid Services). CMS Issues Proposed Rule that Prohibits Discrimination, Reduces Hospital-Acquired Conditions, and Promotes Antibiotic Stewardship in Hospitals. June 13, 2016
TJC (The Joint Commission). New Antimicrobial Stewardship Standard (Prepublication Requirements). June 24, 2016
CDC (Centers for Disease Control and Prevention). Core Elements of Hospital Antibiotic Stewardship Programs. Page last updated: May 25, 2016